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1KLL

Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative

Summary for 1KLL
Entry DOI10.2210/pdb1kll/pdb
Related1KMZ
Descriptormitomycin-binding protein, 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE (3 entities in total)
Functional Keywordsmitomycin c, antibiotic resistance, sad, anomalous diffraction, domain swapping, p-staking, antimicrobial protein
Biological sourceStreptomyces lavendulae
Total number of polymer chains1
Total formula weight14892.19
Authors
Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U. (deposition date: 2001-12-12, release date: 2002-07-19, Last modification date: 2021-10-27)
Primary citationMartin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.H.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U.
Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10:933-942, 2002
Cited by
PubMed: 12121648
DOI: 10.1016/S0969-2126(02)00778-5
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

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