1JMO

Crystal Structure of the Heparin Cofactor II-S195A Thrombin Complex

Summary for 1JMO

• Entry DOI: 10.2210/pdb1jmo/pdb
• Related: 1JMJ
• Descriptor: Thrombin, light chain, Thrombin, heavy chain, HEPARIN COFACTOR II, ... (8 entities in total)
• Functional Keywords: serpin, thrombin, protease, inhibition, inhibitor, blood clotting
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 92073.03

Authors

Baglin, T.P.,Carrell, R.W.,Esmon, C.T.,Huntington, J.A. (deposition date: 2001-07-19, release date: 2002-08-30, Last modification date: 2024-04-03)

• Primary citation: Baglin, T.P.,Carrell, R.W.,Church, F.C.,Esmon, C.T.,Huntington, J.A.; Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism.; Proc.Natl.Acad.Sci.USA, 99:11079-11084, 2002; PubMed: 12169660; DOI: 10.1073/pnas.162232399

Experimental method

X-RAY DIFFRACTION (2.2 Å)