1JLQ

CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94

1JLQ の概要

• エントリーDOI: 10.2210/pdb1jlq/pdb
• 関連するPDBエントリー: 1C0T 1C0U 1C1B 1C1C 1DTQ 1DTT 1EP4 1FK9 1FKO 1FKP 1JKH 1JLA 1JLB 1JLC 1JLE 1JLF 1JLG 1KLM 1REV 1RT1 1RT2 1RT3 1RT4 1RT5 1RT6 1RT7 1RTH 1RTI 1RTJ 1VRT 1VRU
• 分子名称: HIV-1 RT, A-CHAIN, HIV-1 RT, B-CHAIN, 2-AMINO-6-(3,5-DIMETHYLPHENYL)SULFONYLBENZONITRILE (3 entities in total)
• 機能のキーワード: hiv-1 reverse transcriptase, aids, non-nucleoside inhibitor, 739w94, drug design, transferase
• 由来する生物種: HIV-1 M:B_HXB2R; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116280.35

構造登録者

Ren, J.,Stuart, D.I.,Stammers, D.K. (登録日: 2001-07-16, 公開日: 2001-08-22, 最終更新日: 2022-12-21)

• 主引用文献: Chan, J.H.,Hong, J.S.,Hunter III, R.N.,Orr, G.F.,Cowan, J.R.,Sherman, D.B.,Sparks, S.M.,Reitter, B.E.,Andrews III., C.W.,Hazen, R.J.,St Clair, M.,Boone, L.R.,Ferris, R.G.,Creech, K.L.,Roberts, G.B.,Short, S.A.,Weaver, K.,Ott, R.J.,Ren, J.,Hopkins, A.,Stuart, D.I.,Stammers, D.K.; 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.; J.Med.Chem., 44:1866-1882, 2001; PubMed: 11384233; DOI: 10.1021/jm0004906

実験手法

X-RAY DIFFRACTION (3 Å)