1IZI

Inhibitor of HIV protease with unusual binding mode potently inhibiting multi-resistant protease mutants

1IZI の概要

• エントリーDOI: 10.2210/pdb1izi/pdb
• 関連するPDBエントリー: 1IZH
• 分子名称: proteinase, CHLORIDE ION, {(1S)-1-BENZYL-4-[3-CARBAMOYL-1-(1-CARBAMOYL-2-PHENYL-ETHYLCARBAMOYL)-(S)-PROPYLCARBAMOYL]-2-OXO-5-PHENYL-PENTYL}-CARBAMIC ACID TERT-BUTYL ESTER, ... (4 entities in total)
• 機能のキーワード: hiv-1 proteinase, triple mutant, potent inhibitor, subsite binding, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22450.28

構造登録者

Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J. (登録日: 2002-10-02, 公開日: 2002-12-23, 最終更新日: 2023-10-25)

• 主引用文献: Weber, J.,Mesters, J.R.,Lepsik, M.,Prejdova, J.,Svec, M.,Sponarova, J.,Mlcochova, P.,Skalicka, K.,Strisovsky, K.,Uhlikova, T.,Soucek, M.,Machala, L.,Stankova, M.,Vondrasek, J.,Klimkait, T.,Kraeusslich, H.-G.,Hilgenfeld, R.,Konvalinka, J.; Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains; J.MOL.BIOL., 324:739-754, 2002; PubMed: 12460574; DOI: 10.1016/S0022-2836(02)01139-7

実験手法

X-RAY DIFFRACTION (2.15 Å)