1IO4

CRYSTAL STRUCTURE OF RUNX-1/AML1/CBFALPHA RUNT DOMAIN-CBFBETA CORE DOMAIN HETERODIMER AND C/EBPBETA BZIP HOMODIMER BOUND TO A DNA FRAGMENT FROM THE CSF-1R PROMOTER

Summary for 1IO4

Entry DOI	10.2210/pdb1io4/pdb
Related	1CL3 1CMO 1CO1 1E50 1HJB 1HJC 2JHB
Descriptor	CSF-1R PROMOTER, CAAT/ENHANCER BINDING PROTEIN BETA, RUNT-RELATED TRANSCRIPTION FACTOR 1, ... (7 entities in total)
Functional Keywords	protein-dna complex, transcription factor, bzip, runx, runt, c/ebp, cbf, core binding factor, aml1, aml, transcription-dna complex, transcription/dna
Biological source	Homo sapiens (human) More
Cellular location	Nucleus: P17676 Q03347 Nucleus (Potential): Q08024
Total number of polymer chains	6
Total formula weight	65658.31
Authors	Tahirov, T.H.,Ogata, K. (deposition date: 2001-01-10, release date: 2001-03-12, Last modification date: 2023-12-27)
Primary citation	Tahirov, T.H.,Inoue-Bungo, T.,Morii, H.,Fujikawa, A.,Sasaki, M.,Kimura, K.,Shiina, M.,Sato, K.,Kumasaka, T.,Yamamoto, M.,Ishii, S.,Ogata, K. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. Cell(Cambridge,Mass.), 104:755-767, 2001 Cited by PubMed: 11257229 DOI: 10.1016/S0092-8674(01)00271-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation