1IDT
STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE
Summary for 1IDT
| Entry DOI | 10.2210/pdb1idt/pdb |
| Descriptor | MINOR FMN-DEPENDENT NITROREDUCTASE, FLAVIN MONONUCLEOTIDE, 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, ... (4 entities in total) |
| Functional Keywords | fmn, bioreductive activation, prodrug, oxidoreductase |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 49291.42 |
| Authors | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2001-04-05, release date: 2003-09-16, Last modification date: 2023-08-09) |
| Primary citation | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form. J.Med.Chem., 46:4009-4020, 2003 Cited by PubMed: 12954054DOI: 10.1021/jm030843b PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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