2DQT

High resolution crystal structure of the complex of the hydrolytic antibody Fab 6D9 and a transition-state analog

Replaces:  1HYX

Summary for 2DQT

• Entry DOI: 10.2210/pdb2dqt/pdb
• Related: 2DQU
• Descriptor: IMMUNOGLOBULIN 6D9, [1-(3-DIMETHYLAMINO-PROPYL)-3-ETHYL-UREIDO]-[4-(2,2,2-TRIFLUORO-ACETYLAMINO)-BENZYL]PHOSPHINIC ACID-2-(2,2-DIHYDRO-ACETYLAMINO)-3-HYDROXY-1-(4-NITROPHENYL)-PROPYL ESTER, ... (4 entities in total)
• Functional Keywords: catalytic antibody, ester hydrolysis, esterolytic, fab, immunoglobulin, immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 2
• Total formula weight: 48979.38

Authors

Kristensen, O.,Vassylyev, D.G.,Tanaka, F.,Ito, N.,Morikawa, K.,Fujii, I. (deposition date: 2006-05-30, release date: 2006-06-20, Last modification date: 2023-10-25)

• Primary citation: Oda, M.,Ito, N.,Tsumuraya, T.,Suzuki, K.,Sakakura, M.,Fujii, I.; Thermodynamic and structural basis for transition-state stabilization in antibody-catalyzed hydrolysis; J.Mol.Biol., 369:198-209, 2007; PubMed: 17428500; DOI: 10.1016/j.jmb.2007.03.023

Experimental method

X-RAY DIFFRACTION (1.8 Å)