1HE8

Ras G12V - PI 3-kinase gamma complex

Summary for 1HE8

• Entry DOI: 10.2210/pdb1he8/pdb
• Related: 1E8Y 1E8Z
• Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, GAMMA ISOFORM, TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kinase/hydrolase, complex (phosphoinositide kinase-ras), phosphoinositide 3-kinase gamma - h-ras g12v complex, phosphatidylinositol 3-kinase, pi3k, pi 3-k, pi 3-kinase, second messenger generation, ras effector, h-ras g12v, oncogene protein, gmppnp, gtp, ras-binding domain, heat domain, kinase-hydrolase complex
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 130090.72

Authors

Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Hawkins, P.T.,Walker, E.H.,Stephens, L.,Eccleston, J.F.,Williams, R.L. (deposition date: 2000-11-20, release date: 2001-01-08, Last modification date: 2023-12-13)

• Primary citation: Pacold, M.E.,Suire, S.,Perisic, O.,Lara-Gonzalez, S.,Davis, C.T.,Walker, E.H.,Hawkins, P.T.,Stephens, L.,Eccleston, J.F.,Williams, R.L.; Crystal Structure and Functional Analysis of Ras Binding to its Effector Phosphoinositide 3-Kinase Gamma; Cell(Cambridge,Mass.), 103:931-, 2000; PubMed: 11136978; DOI: 10.1016/S0092-8674(00)00196-3

Experimental method

X-RAY DIFFRACTION (3 Å)