1HBJ

X-ray Crystal structure of complex between Torpedo californica AChE and a reversible inhibitor, 4-Amino-5-fluoro-2-methyl-3-(3-trifluoroacetylbenzylthiomethyl)quinoline

Summary for 1HBJ

Entry DOI	10.2210/pdb1hbj/pdb
Related	1ACJ 1ACL 1AMN 1AX9 1CFJ 1DX6 1E3Q 1E66 1EA5 1EEA 1EVE 1FSS 1OCE 1QID 1QIE 1QIF 1QIG 1QIH 1QII 1QIJ 1QIK 1QIM 1QTI 1SOM 1VOT 1VXO 1VXR 2ACE 2ACK 2DFP 3ACE 4ACE
Descriptor	ACETYLCHOLINESTERASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	hydrolase, serine hydrolase, cholinesterase, insecticide
Biological source	TORPEDO CALIFORNICA (PACIFIC ELECTRIC RAY)
Total number of polymer chains	1
Total formula weight	62786.59
Authors	Greenblatt, H.M.,Kryger, G.,Lewis, T.L.,Doucet, C.,Viner, R.,Silman, I.,Sussman, J.L. (deposition date: 2001-04-16, release date: 2001-09-25, Last modification date: 2023-12-13)
Primary citation	Doucet-Personeni, C.,Bentley, P.D.,Fletcher, R.J.,Kinkaid, A.,Kryger, G.,Pirard, B.,Taylor, A.,Taylor, R.,Taylor, J.,Viner, R.,Silman, I.,Sussman, J.L.,Greenblatt, H.M.,Lewis, T.L. A Structure-Based Design Approach to the Development of Novel, Reversible Ache Inhibitors J.Med.Chem., 44:3203-, 2001 Cited by PubMed: 11563919 DOI: 10.1021/JM010826R PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation