1H5U

THE 1.76 A RESOLUTION CRYSTAL STRUCTURE OF GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH GLUCOSE AND CP320626, A POTENTIAL ANTIDIABETIC DRUG

1H5U の概要

• エントリーDOI: 10.2210/pdb1h5u/pdb
• 関連するPDBエントリー: 1A8I 1ABB 1AXR 1B4D 1BX3 1C50 1C8K 1C8L 1E1Y 1FS4 1FTQ 1FTW 1FTY 1FU4 1FU7 1FU8 1GFZ 1GG8 1GGN 1GPA 1GPB 1GPY 1HLF 1NOI 1NOJ 1NOK 1PYG 2AMV 2GPA 2GPB 2GPN 2PRI 2PRJ 2SKC 2SKD 2SKE 3AMV 3GPB 4GPB 5GPB 6GPB 7GPB 8GPB 9GPB
• 分子名称: GLYCOGEN PHOSPHORYLASE, 5-CHLORO-1H-INDOLE-2-CARBOXYLIC ACID [1-(4-FLUOROBENZYL)-2-(4-HYDROXYPIPERIDIN-1YL)-2-OXOETHYL]AMIDE, alpha-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: glycogen metabolism, glycogen phosphorylase b, inhibition, central cavity, drug binding site, transferase
• 由来する生物種: ORYCTOLAGUS CUNICULUS (RABBIT)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98162.40

構造登録者

Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T.,Archontis, G. (登録日: 2001-05-25, 公開日: 2001-06-28, 最終更新日: 2023-12-13)

• 主引用文献: Oikonomakos, N.G.,Zographos, S.E.,Skamnaki, V.T.,Archontis, G.; The 1.76 A Resolution Crystal Structure of Glycogen Phosphorylase B Complexed with Glucose, and Cp320626, a Potential Antidiabetic Drug; Bioorg.Med.Chem., 10:1313-, 2002; PubMed: 11886794; DOI: 10.1016/S0968-0896(01)00394-7

実験手法

X-RAY DIFFRACTION (1.76 Å)