1H15

X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase

Summary for 1H15

Related1A6A 1AQD 1D5M 1D5X 1D5Z 1D6E 1DLH 1FV1 1HQR 1HXY 1J8H 1KG0 1SEB 2SEB
DescriptorHLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR ALPHA CHAIN, HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 1 CHAIN, DNA POLYMERASE, ... (5 entities in total)
Functional Keywordsimmune system/transferase, complex (mhc-antigen), immune system, mhc, hla, class ii, dr2, drb5, ebv, dna polymerase, dna-directed dna polymerase, immune system-transferase complex
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationCell membrane; Single-pass type I membrane protein P01903
Host nucleus P03198
Total number of polymer chains6
Total molecular weight91138.7
Authors
Primary citation
Lang, H.,Jacobsen, H.,Ikemizu, S.,Andersson, C.,Harlos, K.,Madsen, L.,Hjorth, P.,Sondergaard, L.,Svejgaard, A.,Wucherpfennig, K.,Stuart, D.I.,Bell, J.I.,Jones, E.Y.,Fugger, L.
A Functional and Structural Basis for Tcr Cross-Reactivity in Multiple Sclerosis
Nat.Immunol., 3:940-, 2002
PubMed: 12244309 (PDB entries with the same primary citation)
DOI: 10.1038/NI835
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.289384.9%9.4%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution