1GVW

Endothiapepsin complex with PD-130,328

Summary for 1GVW

Entry DOI	10.2210/pdb1gvw/pdb
Related	1E5O 1E80 1E81 1E82 1EED 1ENT 1EPL 1EPM 1EPN 1EPO 1EPP 1EPQ 1EPR 1ER8 1GKT 1GVT 1GVU 1GVV 1GVX 2ER0 2ER6 2ER7 2ER9 3ER3 3ER5 4APE 4ER1 4ER2 4ER4 5ER1 5ER2
Related PRD ID	PRD_000264
Descriptor	ENDOTHIAPEPSIN, N-(tert-butoxycarbonyl)-L-phenylalanyl-N-{(1S)-1-[(R)-hydroxy(2-{[(2S)-2-methylbutyl]amino}-2-oxoethyl)phosphoryl]-3-methylbutyl}-3-(1H-imidazol-3-ium-4-yl)-L-alaninamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, aspartic proteinase mechanism, tetrahedral intermediate, hydrolase- hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	ENDOTHIA PARASITICA (CHESTNUT BLIGHT FUNGUS)
Total number of polymer chains	1
Total formula weight	34651.73
Authors	Coates, L.,Erskine, P.T.,Crump, M.P.,Wood, S.P.,Cooper, J.B. (deposition date: 2002-02-27, release date: 2002-07-04, Last modification date: 2023-11-15)
Primary citation	Coates, L.,Erskine, P.T.,Crump, M.P.,Wood, S.P.,Cooper, J.B. Five Atomic Resolution Structures of Endothiapepsin Inhibitor Complexes: Implications for the Aspartic Proteinase Mechanism J.Mol.Biol., 318:1405-, 2002 Cited by PubMed: 12083527 DOI: 10.1016/S0022-2836(02)00197-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1 Å)

Structure validation