1GMY

Cathepsin B complexed with dipeptidyl nitrile inhibitor

1GMY の概要

• エントリーDOI: 10.2210/pdb1gmy/pdb
• 関連するPDBエントリー: 1CSB 1HUC 1PBH 2PBH 3PBH
• 分子名称: CATHEPSIN B, 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, ... (5 entities in total)
• 機能のキーワード: hydrolase/inhibitor, complex (hydrolase-inhibitor), covalent complex, protease, cathepsin b, hydrolase, thiol protease, hydrolase-inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Lysosome : P07858
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 87812.00

構造登録者

Greenspan, P.D.,Clark, K.L.,Tommasi, R.A.,Cowen, S.D.,McQuire, L.W.,Farley, D.L.,van Duzer, J.H.,Goldberg, R.L.,Zhou, H.,Du, Z.,Fitt, J.J.,Coppa, D.E.,Fang, Z.,Macchia, W.,Zhu, L.,Capparelli, M.P.,Goldstein, R.,Wigg, A.M.,Doughty, J.R.,Bohacek, R.S.,Knap, A.K. (登録日: 2001-09-25, 公開日: 2002-09-19, 最終更新日: 2017-07-05)

• 主引用文献: Greenspan, P.D.,Clark, K.L.,Tommasi, R.A.,Cowen, S.D.,Mcquire, L.W.,Farley, D.L.,Van Duzer, J.H.,Goldberg, R.L.,Zhou, H.,Du, Z.,Fitt, J.J.,Coppa, D.E.,Fang, Z.,Macchia, W.,Zhu, L.,Capparelli, M.P.,Goldstein, R.,Wigg, A.M.,Doughty, J.R.,S Bohacek, R.,Knap, A.K.; Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design; J.Med.Chem., 44:4524-, 2001; PubMed: 11741472; DOI: 10.1021/JM010206Q

実験手法

X-RAY DIFFRACTION (1.9 Å)