1GKC

MMP9-inhibitor complex

1GKC の概要

• エントリーDOI: 10.2210/pdb1gkc/pdb
• 分子名称: 92 KDA TYPE IV COLLAGENASE, CALCIUM ION, N~2~-[(2R)-2-{[formyl(hydroxy)amino]methyl}-4-methylpentanoyl]-N,3-dimethyl-L-valinamide, ... (5 entities in total)
• 機能のキーワード: matrix metalloprotease, hydrolase, glycoprotein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix (Probable): P14780
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38062.05

構造登録者

Rowsell, S.,Pauptit, R.A. (登録日: 2001-08-10, 公開日: 2002-05-16, 最終更新日: 2023-12-13)

• 主引用文献: Rowsell, S.,Hawtin, P.,Minshull, C.A.,Jepson, H.,Brockbank, S.,Barratt, D.,Slater, A.M.,Mcpheat, W.,Waterson, D.,Henney, A.,Pauptit, R.A.; Crystal Structure of Mmp9 in Complex with a Reverse Hydroxamate Inhibitor; J.Mol.Biol., 319:173-, 2002; PubMed: 12051944; DOI: 10.1016/S0022-2836(02)00262-0

実験手法

X-RAY DIFFRACTION (2.3 Å)