1GG5

CRYSTAL STRUCTURE OF A COMPLEX OF HUMAN NAD[P]H-QUINONE OXIDOREDUCTASE AND A CHEMOTHERAPEUTIC DRUG (E09) AT 2.5 A RESOLUTION

Summary for 1GG5

Entry DOI	10.2210/pdb1gg5/pdb
Descriptor	NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE, 3-HYDROXYMETHYL-5-AZIRIDINYL-1METHYL-2-[1H-INDOLE-4,7-DIONE]-PROPANOL, ... (4 entities in total)
Functional Keywords	flavoprotein, rossmann fold, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15559
Total number of polymer chains	4
Total formula weight	127409.10
Authors	Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. (deposition date: 2000-07-12, release date: 2001-09-12, Last modification date: 2023-12-27)
Primary citation	Faig, M.,Bianchet, M.A.,Winski, S.,Hargreaves, R.,Moody, C.J.,Hudnott, A.R.,Ross, D.,Amzel, L.M. Structure-based development of anticancer drugs: complexes of NAD(P)H:quinone oxidoreductase 1 with chemotherapeutic quinones. Structure, 9:659-667, 2001 Cited by PubMed: 11587640 DOI: 10.1016/S0969-2126(01)00636-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation