1G65

Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors

1G65 の概要

関連するPDBエントリー1RYP 1G0U 1PMA
分子名称Proteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (17 entities in total)
機能のキーワードproteasome, epoxomicin, ubiquitin, ntn-hydolase, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
由来する生物種Saccharomyces cerevisiae (Baker's yeast)
詳細
細胞内の位置Cytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
ポリマー鎖数30
分子量合計705534.79
構造登録者
Groll, M.,Kim, K.B.,Kairies, N.,Huber, R.,Crews, C. (登録日: 2000-11-03, 公開日: 2000-11-27, 最終更新日: 2011-07-13)
主引用文献
Groll, M.,Kim, K.B.,Kairies, N.,Crews, C.
Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors
J.Am.Chem.Soc., 122:1237-1238, 2000
DOI: 10.1021/ja993588m
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.25 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers171.3%6.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード