1G5S

CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717

Summary for 1G5S

DescriptorCELL DIVISION PROTEIN KINASE 2, 2-[TRANS-(4-AMINOCYCLOHEXYL)AMINO]-6-(BENZYL-AMINO)-9-CYCLOPENTYLPURINE (3 entities in total)
Functional Keywordsprotein-inhibitor complex, cell cycle-transferase complex, cell cycle/transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome P24941
Total number of polymer chains1
Total molecular weight34382.03
Authors
Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.-H. (deposition date: 2000-11-02, release date: 2001-11-02, Last modification date: 2018-04-04)
Primary citation
Dreyer, M.K.,Borcherding, D.R.,Dumont, J.A.,Peet, N.P.,Tsay, J.T.,Wright, P.S.,Bitonti, A.J.,Shen, J.,Kim, S.H.
Crystal structure of human cyclin-dependent kinase 2 in complex with the adenine-derived inhibitor H717.
J.Med.Chem., 44:524-530, 2001
PubMed: 11170642 (PDB entries with the same primary citation)
DOI: 10.1021/jm001043t
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.61 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers221.5%7.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report