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1FVV

THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR

Summary for 1FVV
Entry DOI10.2210/pdb1fvv/pdb
DescriptorCYCLIN-DEPENDENT KINASE 2, CYCLIN A, 4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE, ... (4 entities in total)
Functional Keywordscyclin-dependent kinase, cyclin a, transferase, cell cycle
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
Nucleus : P20248
Total number of polymer chains4
Total formula weight128587.01
Authors
Primary citationDavis, S.T.,Benson, B.G.,Bramson, H.N.,Chapman, D.E.,Dickerson, S.H.,Dold, K.M.,Eberwein, D.J.,Edelstein, M.,Frye, S.V.,Gampe Jr, R.T.,Griffin, R.J.,Harris, P.A.,Hassell, A.M.,Holmes, W.D.,Hunter, R.N.,Knick, V.B.,Lackey, K.,Lovejoy, B.,Luzzio, M.J.,Murray, D.,Parker, P.,Rocque, W.J.,Shewchuk, L.,Veal, J.M.,Walker, D.H.,Kuyper, L.F.
Prevention of chemotherapy-induced alopecia in rats by CDK inhibitors.
Science, 291:134-137, 2001
Cited by
PubMed: 11141566
DOI: 10.1126/science.291.5501.134
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.8 Å)
Structure validation

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