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1FGC

STRUCTURAL IMPLICATIONS OF DRUG RESISTANT MUTANTS OF HIV-1 PROTEASE: HIGH RESOLUTION CRYSTAL STRUCTURES OF THE MUTANT PROTEASE/SUBSTRATE ANALOG COMPLEXES

Summary for 1FGC
Entry DOI10.2210/pdb1fgc/pdb
Related1a94 1daz
Related PRD IDPRD_000398
DescriptorPROTEASE RETROPEPSIN, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide (3 entities in total)
Functional Keywordshiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
Total number of polymer chains2
Total formula weight22252.34
Authors
Mahalingam, B.,Louis, J.M.,Harrison, R.W.,Weber, I.T. (deposition date: 2000-07-28, release date: 2001-06-01, Last modification date: 2024-03-13)
Primary citationMahalingam, B.,Louis, J.M.,Hung, J.,Harrison, R.W.,Weber, I.T.
Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes.
Proteins, 43:455-464, 2001
Cited by
PubMed: 11340661
DOI: 10.1002/prot.1057
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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