1EFY

CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF POLY (ADP-RIBOSE) POLYMERASE COMPLEXED WITH A BENZIMIDAZOLE INHIBITOR

Summary for 1EFY

Entry DOI	10.2210/pdb1efy/pdb
Related	1PAX 2PAW 2PAX 3PAX 4PAX
Descriptor	POLY (ADP-RIBOSE) POLYMERASE, 2-(3'-METHOXYPHENYL) BENZIMIDAZOLE-4-CARBOXAMIDE (3 entities in total)
Functional Keywords	benzimidazole, inhibitor, catalytic fragment, polymerase, transferase
Biological source	Gallus gallus (chicken)
Cellular location	Nucleus : P26446
Total number of polymer chains	1
Total formula weight	39595.42
Authors	White, A.W.,Almassy, R.,Calvert, A.H.,Curtin, N.J.,Griffin, R.J.,Hostomsky, Z.,Maegley, K.,Newell, D.R.,Srinivasan, S.,Golding, B.T. (deposition date: 2000-02-10, release date: 2001-01-17, Last modification date: 2024-02-07)
Primary citation	White, A.W.,Almassy, R.,Calvert, A.H.,Curtin, N.J.,Griffin, R.J.,Hostomsky, Z.,Maegley, K.,Newell, D.R.,Srinivasan, S.,Golding, B.T. Resistance-modifying agents. 9. Synthesis and biological properties of benzimidazole inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase. J.Med.Chem., 43:4084-4097, 2000 Cited by PubMed: 11063605 DOI: 10.1021/jm000950v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation