1DW6

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

1DW6 の概要

• エントリーDOI: 10.2210/pdb1dw6/pdb
• 関連するPDBエントリー: 1EBK 1a94 1daz
• 関連するBIRD辞書のPRD_ID: PRD_000349
• 分子名称: HIV-1 PROTEASE, N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
• 機能のキーワード: hiv-1 protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22350.48

構造登録者

Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. (登録日: 2000-01-24, 公開日: 2000-07-26, 最終更新日: 2024-02-07)

• 主引用文献: Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.; Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.; Eur.J.Biochem., 263:238-245, 1999; PubMed: 10429209; DOI: 10.1046/j.1432-1327.1999.00514.x

実験手法

X-RAY DIFFRACTION (1.88 Å)