1DSI

Solution structure of a duocarmycin sa-indole-alkylated dna dupleX

1DSI の概要

• エントリーDOI: 10.2210/pdb1dsi/pdb
• 分子名称: DNA (5'-D(*GP*AP*CP*TP*AP*AP*TP*TP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*AP*AP*TP*TP*AP*GP*TP*C)-3'), 4-HYDROXY-6-(1H-INDOLE-2-CARBONYL)-8-METHYL-3,6,7,8-TETRAHYDRO-3,6-DIAZA-AS-INDACENE-2-CARBOXYLIC ACID METHYL ESTER (3 entities in total)
• 機能のキーワード: deoxyribonucleic acid, duocarmycin, dna, minor groove binding, antitumor agent, ligand-dna complex
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7094.84

構造登録者

Schnell, J.R.,Ketchem, R.R.,Boger, D.L.,Chazin, W.J. (登録日: 1998-07-29, 公開日: 1998-08-05, 最終更新日: 2022-02-16)

• 主引用文献: Schnell, J.R.,Ketchem, R.R.,Boger, D.L.,Chazin, W.J.; Binding-Induced Activation of DNA Alkylation by Duocarmycin SA: Insights from the Structure of an Indole Derivative-DNA Adduct; J.Am.Chem.Soc., 121:5645-5652, 1999; DOI: 10.1021/ja983556j

実験手法

SOLUTION NMR