1DRA

CRYSTAL STRUCTURE OF UNLIGANDED ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE. LIGAND-INDUCED CONFORMATIONAL CHANGES AND COOPERATIVITY IN BINDING

Summary for 1DRA

Entry DOI	10.2210/pdb1dra/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, CHLORIDE ION, METHOTREXATE, ... (5 entities in total)
Functional Keywords	oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	37088.57
Authors	Oatley, S.J.,Kraut, J. (deposition date: 1991-11-06, release date: 1994-01-31, Last modification date: 2024-02-07)
Primary citation	Bystroff, C.,Kraut, J. Crystal structure of unliganded Escherichia coli dihydrofolate reductase. Ligand-induced conformational changes and cooperativity in binding. Biochemistry, 30:2227-2239, 1991 Cited by PubMed: 1998681 DOI: 10.1021/bi00222a028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation