1DIF

HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285

Summary for 1DIF

Entry DOI	10.2210/pdb1dif/pdb
Descriptor	HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE, ... (4 entities in total)
Functional Keywords	aspartic proteinase
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	2
Total formula weight	22594.74
Authors	Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. (deposition date: 1995-10-09, release date: 1996-03-08, Last modification date: 2011-07-13)
Primary citation	Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. Inhibition and catalytic mechanism of HIV-1 aspartic protease. J.Mol.Biol., 255:321-346, 1996 Cited by PubMed: 8551523 DOI: 10.1006/jmbi.1996.0026 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation