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1DI9

THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE

Summary for 1DI9
Entry DOI10.2210/pdb1di9/pdb
Related1DI8
DescriptorP38 KINASE, 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE (3 entities in total)
Functional Keywordsserine/threonine protein kinase, map kinase, p38, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity): Q16539
Total number of polymer chains1
Total formula weight41670.60
Authors
Shewchuk, L.,Hassell, A.,Kuyper, L.F. (deposition date: 1999-11-29, release date: 2000-11-29, Last modification date: 2024-02-07)
Primary citationShewchuk, L.,Hassell, A.,Wisely, B.,Rocque, W.,Holmes, W.,Veal, J.,Kuyper, L.F.
Binding mode of the 4-anilinoquinazoline class of protein kinase inhibitor: X-ray crystallographic studies of 4-anilinoquinazolines bound to cyclin-dependent kinase 2 and p38 kinase.
J.Med.Chem., 43:133-138, 2000
Cited by
PubMed: 10633045
DOI: 10.1021/jm990401t
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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