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1DAZ

Structural and kinetic analysis of drug resistant mutants of HIV-1 protease

Summary for 1DAZ
Entry DOI10.2210/pdb1daz/pdb
Related1A94
Related PRD IDPRD_000349
DescriptorHIV-1 PROTEASE (RETROPEPSIN), N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide (3 entities in total)
Functional Keywordshiv-1 protease, hydrolase-hydrolase inhibitor complex, reduced peptide inhibitor, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains2
Total formula weight22282.36
Authors
Mahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T. (deposition date: 1999-11-01, release date: 2000-05-03, Last modification date: 2024-03-13)
Primary citationMahalingam, B.,Louis, J.M.,Reed, C.C.,Adomat, J.M.,Krouse, J.,Wang, Y.F.,Harrison, R.W.,Weber, I.T.
Structural and kinetic analysis of drug resistant mutants of HIV-1 protease.
Eur.J.Biochem., 263:238-245, 1999
Cited by
PubMed: 10429209
DOI: 10.1046/j.1432-1327.1999.00514.x
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

217705

数据于2024-03-27公开中

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