1D5Z

X-RAY CRYSTAL STRUCTURE OF HLA-DR4 COMPLEXED WITH PEPTIDOMIMETIC AND SEB

Summary for 1D5Z

Related1D5M 1D5X 1D6E
Related PRD IDPRD_000456
DescriptorPROTEIN (HLA CLASS II HISTOCOMPATIBILITY ANTIGEN), PROTEIN (ENTEROTOXIN TYPE B), PROTEIN (PEPTIDOMIMETIC INHIBITOR), ... (5 entities in total)
Functional Keywordsmhc class ii-superantigen complex, immune system-peptide inhibitor complex, peptidomimetic inhibitor, immune system/peptide inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane; Single-pass type I membrane protein P01903 P13760
Secreted P01552
Total number of polymer chains4
Total molecular weight72862.93
Authors
Swain, A.,Crowther, R.,Kammlott, U. (deposition date: 1999-10-12, release date: 2000-06-28, Last modification date: 2012-12-12)
Primary citation
Bolin, D.R.,Swain, A.L.,Sarabu, R.,Berthel, S.J.,Gillespie, P.,Huby, N.J.,Makofske, R.,Orzechowski, L.,Perrotta, A.,Toth, K.,Cooper, J.P.,Jiang, N.,Falcioni, F.,Campbell, R.,Cox, D.,Gaizband, D.,Belunis, C.J.,Vidovic, D.,Ito, K.,Crowther, R.,Kammlott, U.,Zhang, X.,Palermo, R.,Weber, D.,Guenot, J.,Nagy, Z.,Olson, G.L.
Peptide and peptide mimetic inhibitors of antigen presentation by HLA-DR class II MHC molecules. Design, structure-activity relationships, and X-ray crystal structures.
J.Med.Chem., 43:2135-2148, 2000
PubMed: 10841792 (PDB entries with the same primary citation)
DOI: 10.1021/jm000034h
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers1502.4%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution