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1CVU

CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2

Summary for 1CVU
Entry DOI10.2210/pdb1cvu/pdb
Related1CQE 1LOX 5COX 6COX
DescriptorPROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywordscox-2, cyclooxygenase, prostaglandin, arachidonate, endoperoxide, oxidoreductase-peptide complex, oxidoreductase/peptide
Biological sourceMus musculus (house mouse)
Total number of polymer chains3
Total formula weight132599.08
Authors
Kiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G. (deposition date: 1999-08-24, release date: 2000-05-16, Last modification date: 2021-11-03)
Primary citationKiefer, J.R.,Pawlitz, J.L.,Moreland, K.T.,Stegeman, R.A.,Hood, W.F.,Gierse, J.K.,Stevens, A.M.,Goodwin, D.C.,Rowlinson, S.W.,Marnett, L.J.,Stallings, W.C.,Kurumbail, R.G.
Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405:97-101, 2000
Cited by
PubMed: 10811226
DOI: 10.1038/35011103
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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