1BIS

HIV-1 INTEGRASE CORE DOMAIN

Summary for 1BIS

Entry DOI	10.2210/pdb1bis/pdb
Descriptor	HIV-1 INTEGRASE (2 entities in total)
Functional Keywords	dna integration, integrase, hiv, hydrolase, aspartyl protease, endonuclease
Biological source	Human immunodeficiency virus 1
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P12497
Total number of polymer chains	2
Total formula weight	36269.29
Authors	Goldgur, Y.,Dyda, F.,Hickman, A.B.,Jenkins, T.M.,Craigie, R.,Davies, D.R. (deposition date: 1998-06-19, release date: 1998-08-19, Last modification date: 2023-08-02)
Primary citation	Goldgur, Y.,Dyda, F.,Hickman, A.B.,Jenkins, T.M.,Craigie, R.,Davies, D.R. Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium. Proc.Natl.Acad.Sci.USA, 95:9150-9154, 1998 Cited by PubMed: 9689049 DOI: 10.1073/pnas.95.16.9150 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation