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1BGQ

RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE

Summary for 1BGQ
Entry DOI10.2210/pdb1bgq/pdb
DescriptorHEAT SHOCK PROTEIN 90, RADICICOL (3 entities in total)
Functional Keywordschaperone, atp-binding, heat shock, inhibitor
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationCytoplasm: P02829
Total number of polymer chains1
Total formula weight25891.81
Authors
Roe, S.M.,Prodromou, C.,Pearl, L.H. (deposition date: 1998-05-29, release date: 1999-06-08, Last modification date: 2023-08-02)
Primary citationRoe, S.M.,Prodromou, C.,O'Brien, R.,Ladbury, J.E.,Piper, P.W.,Pearl, L.H.
Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42:260-266, 1999
Cited by
PubMed: 9925731
DOI: 10.1021/jm980403y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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