1BC8

STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS

Summary for 1BC8

• Entry DOI: 10.2210/pdb1bc8/pdb
• Descriptor: DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), DNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), PROTEIN (SAP-1 ETS DOMAIN), ... (5 entities in total)
• Functional Keywords: ets domain, dna-binding domain, winged helix-turn-helix, dna-binding specificity, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: P28324
• Total number of polymer chains: 3
• Total formula weight: 17439.04

Authors

Mo, Y.,Vaessen, B.,Johnston, K.,Marmorstein, R. (deposition date: 1998-05-05, release date: 1998-12-01, Last modification date: 2024-02-07)

• Primary citation: Mo, Y.,Vaessen, B.,Johnston, K.,Marmorstein, R.; Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.; Mol.Cell, 2:201-212, 1998; PubMed: 9734357; DOI: 10.1016/S1097-2765(00)80130-6

Experimental method

X-RAY DIFFRACTION (1.93 Å)