1AXA

ACTIVE-SITE MOBILITY IN HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE AS DEMONSTRATED BY CRYSTAL STRUCTURE OF A28S MUTANT

1AXA の概要

• エントリーDOI: 10.2210/pdb1axa/pdb
• 分子名称: HIV-1 PROTEASE, N-[[1-[N-ACETAMIDYL]-[1-CYCLOHEXYLMETHYL-2-HYDROXY-4-ISOPROPYL]-BUT-4-YL]-CARBONYL]-GLUTAMINYL-ARGINYL-AMIDE (3 entities in total)
• 機能のキーワード: hiv protease, mutant, aspartic protease, hydrolase, acid proteinase, aspartyl protease
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22833.04

構造登録者

Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J. (登録日: 1997-10-13, 公開日: 1998-04-15, 最終更新日: 2024-02-07)

• 主引用文献: Hong, L.,Hartsuck, J.A.,Foundling, S.,Ermolieff, J.,Tang, J.; Active-site mobility in human immunodeficiency virus, type 1, protease as demonstrated by crystal structure of A28S mutant.; Protein Sci., 7:300-305, 1998; PubMed: 9521105

実験手法

X-RAY DIFFRACTION (2 Å)