1ADG

CRYSTALLOGRAPHIC STUDIES OF TWO ALCOHOL DEHYDROGENASE-BOUND ANALOGS OF THIAZOLE-4-CARBOXAMIDE ADENINE DINUCLEOTIDE (TAD), THE ACTIVE ANABOLITE OF THE ANTITUMOR AGENT TIAZOFURIN

Summary for 1ADG

• Entry DOI: 10.2210/pdb1adg/pdb
• Descriptor: ALCOHOL DEHYDROGENASE, ZINC ION, BETA-METHYLENE-SELENAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: oxidoreductase(nad(a)-choh(d))
• Biological source: Equus caballus (horse)
• Cellular location: Cytoplasm: P00327
• Total number of polymer chains: 1
• Total formula weight: 40698.47

Authors

Li, H.,Hallows, W.A.,Punzi, J.S.,Marquez, V.E.,Carrell, H.L.,Pankiewicz, K.W.,Watanabe, K.A.,Goldstein, B.M. (deposition date: 1993-10-18, release date: 1994-01-31, Last modification date: 2024-02-07)

• Primary citation: Li, H.,Hallows, W.H.,Punzi, J.S.,Marquez, V.E.,Carrell, H.L.,Pankiewicz, K.W.,Watanabe, K.A.,Goldstein, B.M.; Crystallographic studies of two alcohol dehydrogenase-bound analogues of thiazole-4-carboxamide adenine dinucleotide (TAD), the active anabolite of the antitumor agent tiazofurin.; Biochemistry, 33:23-32, 1994; PubMed: 8286346; DOI: 10.1021/bi00167a004

Experimental method

X-RAY DIFFRACTION (2.7 Å)