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1A72

AN ACTIVE-SITE DOUBLE MUTANT (PHE93->TRP, VAL203->ALA) OF HORSE LIVER ALCOHOL DEHYDROGENASE IN COMPLEX WITH THE ISOSTERIC NAD ANALOG CPAD

Summary for 1A72
Entry DOI10.2210/pdb1a72/pdb
DescriptorHORSE LIVER ALCOHOL DEHYDROGENASE, ZINC ION, 5-BETA-D-RIBOFURANOSYLPICOLINAMIDE ADENINE-DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsoxidoreductase (nad(a)-choh(d)), active site mutant, liver alcohol dehydrogenase, isosteric nad inhibitors, oxidoreductase
Biological sourceEquus caballus (horse)
Cellular locationCytoplasm: P00327
Total number of polymer chains1
Total formula weight40658.50
Authors
Colby, T.D.,Bahnson, B.J.,Chin, J.K.,Klinman, J.P.,Goldstein, B.M. (deposition date: 1998-03-19, release date: 1998-06-17, Last modification date: 2023-08-02)
Primary citationColby, T.D.,Bahnson, B.J.,Chin, J.K.,Klinman, J.P.,Goldstein, B.M.
Active site modifications in a double mutant of liver alcohol dehydrogenase: structural studies of two enzyme-ligand complexes.
Biochemistry, 37:9295-9304, 1998
Cited by
PubMed: 9649310
DOI: 10.1021/bi973184b
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.6 Å)
Structure validation

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