1A5V

ASV INTEGRASE CORE DOMAIN WITH HIV-1 INTEGRASE INHIBITOR Y3 AND MN CATION

Summary for 1A5V

Entry DOI	10.2210/pdb1a5v/pdb
Descriptor	INTEGRASE, MANGANESE (II) ION, 4-ACETYLAMINO-5-HYDROXYNAPHTHALENE-2,7-DISULFONIC ACID, ... (4 entities in total)
Functional Keywords	hydrolase, endonuclease, hiv-1 integrase inhibitor
Biological source	Rous sarcoma virus (strain Schmidt-Ruppin)
Cellular location	Matrix protein p19: Virion (Potential). Capsid protein p27: Virion (Potential). Nucleocapsid protein p12: Virion (Potential): P03354
Total number of polymer chains	1
Total formula weight	17815.21
Authors	Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A. (deposition date: 1998-02-18, release date: 1998-05-27, Last modification date: 2023-08-02)
Primary citation	Lubkowski, J.,Yang, F.,Alexandratos, J.,Wlodawer, A.,Zhao, H.,Burke Jr., T.R.,Neamati, N.,Pommier, Y.,Merkel, G.,Skalka, A.M. Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor. Proc.Natl.Acad.Sci.USA, 95:4831-4836, 1998 Cited by PubMed: 9560188 DOI: 10.1073/pnas.95.9.4831 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation