1A0N

NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, FAMILY OF 25 STRUCTURES

Summary for 1A0N

• Entry DOI: 10.2210/pdb1a0n/pdb
• Descriptor: PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN (2 entities in total)
• Functional Keywords: complex (phosphotransferase-peptide), sh3 domain, polyproline-binding, complex (phosphotransferase-peptide) complex, complex (phosphotransferase/peptide)
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: P06241
• Total number of polymer chains: 2
• Total formula weight: 9103.88

Authors

Renzoni, D.A.,Pugh, D.J.R.,Siligardi, G.,Das, P.,Morton, C.J.,Rossi, C.,Waterfield, M.D.,Campbell, I.D.,Ladbury, J.E. (deposition date: 1997-12-05, release date: 1998-02-25, Last modification date: 2022-02-16)

• Primary citation: Renzoni, D.A.,Pugh, D.J.,Siligardi, G.,Das, P.,Morton, C.J.,Rossi, C.,Waterfield, M.D.,Campbell, I.D.,Ladbury, J.E.; Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase.; Biochemistry, 35:15646-15653, 1996; PubMed: 8961927; DOI: 10.1021/bi9620969

Experimental method

SOLUTION NMR