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1YKR

Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor

Summary for 1YKR
Entry DOI10.2210/pdb1ykr/pdb
DescriptorCell division protein kinase 2, 4-{[6-(2,6-DICHLOROBENZOYL)IMIDAZO[1,2-A]PYRIDIN-2-YL]AMINO}BENZENESULFONAMIDE (3 entities in total)
Functional Keywordscell cycle division protein kinase 2, cdk2, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight34437.81
Authors
Hamdouchi, C.,Zhong, B.,Mendoza, J.,Jaramillo, C.,Zhang, F.,Brooks, H.B. (deposition date: 2005-01-18, release date: 2006-01-24, Last modification date: 2023-08-23)
Primary citationHamdouchi, C.,Zhong, B.,Mendoza, J.,Collins, E.,Jaramillo, C.,De Diego, J.E.,Robertson, D.,Spencer, C.D.,Anderson, B.D.,Watkins, S.A.,Zhang, F.,Brooks, H.B.
Structure-based design of a new class of highly selective aminoimidazo[1,2-a]pyridine-based inhibitors of cyclin dependent kinases
Bioorg.Med.Chem.Lett., 15:1943-1947, 2005
Cited by
PubMed: 15780638
DOI: 10.1016/j.bmcl.2005.01.052
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

217705

数据于2024-03-27公开中

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