1YI4

Structure of Pim-1 bound to adenosine

Summary for 1YI4

• Entry DOI: 10.2210/pdb1yi4/pdb
• Related: 1YHS 1YI3
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, ADENOSINE (3 entities in total)
• Functional Keywords: protein kinase, proto oncogene, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 31941.13

Authors

Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K. (deposition date: 2005-01-11, release date: 2005-01-25, Last modification date: 2011-07-13)

• Primary citation: Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K.; Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.; J.Biol.Chem., 280:13728-13734, 2005; PubMed: 15657054; DOI: 10.1074/jbc.M413155200

Experimental method

X-RAY DIFFRACTION (2.4 Å)