1YI3

Crystal Structure of Pim-1 bound to LY294002

Summary for 1YI3

• Entry DOI: 10.2210/pdb1yi3/pdb
• Related: 1YHS
• Descriptor: Proto-oncogene serine/threonine-protein kinase Pim-1, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE (3 entities in total)
• Functional Keywords: protein kinase, pi3k, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
• Total number of polymer chains: 1
• Total formula weight: 31981.24

Authors

Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K. (deposition date: 2005-01-11, release date: 2005-01-25, Last modification date: 2017-10-11)

• Primary citation: Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K.; Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.; J.Biol.Chem., 280:13728-13734, 2005; PubMed: 15657054; DOI: 10.1074/jbc.M413155200

Experimental method

X-RAY DIFFRACTION (2.5 Å)