1YHS

Crystal structure of Pim-1 bound to staurosporine

Summary for 1YHS

Entry DOI	10.2210/pdb1yhs/pdb
Descriptor	Proto-oncogene serine/threonine-protein kinase Pim-1, STAUROSPORINE (3 entities in total)
Functional Keywords	protein kinase, proto-oncogene, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 2: Cytoplasm. Isoform 1: Cell membrane: P11309
Total number of polymer chains	1
Total formula weight	32140.42
Authors	Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K. (deposition date: 2005-01-10, release date: 2005-01-25, Last modification date: 2018-01-31)
Primary citation	Jacobs, M.D.,Black, J.,Futer, O.,Swenson, L.,Hare, B.,Fleming, M.,Saxena, K. Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J.Biol.Chem., 280:13728-13734, 2005 Cited by PubMed: 15657054 DOI: 10.1074/jbc.M413155200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation