1YCQ
XENOPUS LAEVIS MDM2 BOUND TO THE TRANSACTIVATION DOMAIN OF HUMAN P53
Summary for 1YCQ
| Entry DOI | 10.2210/pdb1ycq/pdb |
| Descriptor | MDM2, P53 (3 entities in total) |
| Functional Keywords | anti-oncogene, dna-binding, transcription regulation, nuclear protein, complex (oncogene protein-peptide), phosphorylation, activator, complex (oncogene protein-peptide) complex, complex (oncogene protein/peptide) |
| Biological source | Xenopus laevis (African clawed frog) |
| Total number of polymer chains | 2 |
| Total formula weight | 14184.10 |
| Authors | Kussie, P.H.,Pavletich, N.P. (deposition date: 1996-09-30, release date: 1997-11-19, Last modification date: 2024-02-14) |
| Primary citation | Kussie, P.H.,Gorina, S.,Marechal, V.,Elenbaas, B.,Moreau, J.,Levine, A.J.,Pavletich, N.P. Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain. Science, 274:948-953, 1996 Cited by PubMed: 8875929DOI: 10.1126/science.274.5289.948 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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