1YCI

Factor inhibiting HIF-1 alpha in complex with N-(carboxycarbonyl)-D-phenylalanine

Summary for 1YCI

Entry DOI	10.2210/pdb1yci/pdb
Related	1H2K 1H2L 1H2M 1H2N
Descriptor	Hypoxia-inducible factor 1 alpha inhibitor, FE (II) ION, SULFATE ION, ... (5 entities in total)
Functional Keywords	fih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, hydroxylase n-(carboxycarbonyl)-d-phenylalanine, nofd, ndf, transcription regulator, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Nucleus (Potential): Q9NWT6
Total number of polymer chains	1
Total formula weight	41146.73
Authors	McDonough, M.A.,Schofield, C.J. (deposition date: 2004-12-22, release date: 2005-05-31, Last modification date: 2023-10-25)
Primary citation	McDonough, M.A.,McNeill, L.A.,Tilliet, M.,Papamicael, C.A.,Chen, Q.Y.,Banerji, B.,Hewitson, K.S.,Schofield, C.J. Selective inhibition of factor inhibiting hypoxia-inducible factor J.Am.Chem.Soc., 127:7680-7681, 2005 Cited by PubMed: 15913349 DOI: 10.1021/ja050841b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation