1Y8Y

Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor

Summary for 1Y8Y

Entry DOI	10.2210/pdb1y8y/pdb
Descriptor	Cell division protein kinase 2, (5-CHLOROPYRAZOLO[1,5-A]PYRIMIDIN-7-YL)-(4-METHANESULFONYLPHENYL)AMINE (3 entities in total)
Functional Keywords	serine/threonine protein kinase, cdk2, atp-binding, cell cycle, mitosis, phosphorylation, pyrazolopyrimidine inhibitor, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	34299.26
Authors	Williamson, D.S.,Parratt, M.J.,Torrance, C.J.,Bower, J.F.,Moore, J.D.,Richardson, C.M.,Dokurno, P.,Cansfield, A.D.,Francis, G.L.,Hebdon, R.J.,Howes, R.,Jackson, P.S.,Lockie, A.M.,Murray, J.B.,Nunns, C.L.,Powles, J.,Robertson, A.,Surgenor, A.E. (deposition date: 2004-12-14, release date: 2005-02-08, Last modification date: 2023-08-23)
Primary citation	Williamson, D.S.,Parratt, M.J.,Bower, J.F.,Moore, J.D.,Richardson, C.M.,Dokurno, P.,Cansfield, A.D.,Francis, G.L.,Hebdon, R.J.,Howes, R.,Jackson, P.S.,Lockie, A.M.,Murray, J.B.,Nunns, C.L.,Powles, J.,Robertson, A.,Surgenor, A.E.,Torrance, C.J. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg.Med.Chem.Lett., 15:863-867, 2005 Cited by PubMed: 15686876 DOI: 10.1016/j.bmcl.2004.12.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.996 Å)

Structure validation