1XS7
Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
1XS7 の概要
エントリーDOI | 10.2210/pdb1xs7/pdb |
分子名称 | Beta-secretase 1, N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4 -ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE (2 entities in total) |
機能のキーワード | beta secretase, memapsin2, bace, asp2, aspartic protease, acid protease, alzheimer's disease, drug design, hydrolase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein: P56817 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 44043.74 |
構造登録者 | Ghosh, A.,Devasamudram, T.,Hong, L.,DeZutter, C.,Xu, X.,Weerasena, V.,Koelsch, G.,Bilcer, G.,Tang, J. (登録日: 2004-10-18, 公開日: 2004-12-21, 最終更新日: 2023-08-23) |
主引用文献 | Ghosh, A.K.,Devasamudram, T.,Hong, L.,Dezutter, C.,Xu, X.,Weerasena, V.,Koelsch, G.,Bilcer, G.,Tang, J. Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase). Bioorg.Med.Chem.Lett., 15:15-20, 2005 Cited by PubMed: 15582402DOI: 10.1016/j.bmcl.2004.10.084 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.8 Å) |
構造検証レポート
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