1XH6

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

1XH6 の概要

• エントリーDOI: 10.2210/pdb1xh6/pdb
• 関連するPDBエントリー: 1SVE 1SVG 1SVH 1VEB 1XH4 1XH5 1XH7 1XH8 1XH9 1XHA
• 分子名称: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-(4-{[4-(2-HYDROXY-5-PIPERIDIN-1-YLBENZOYL)BENZOYL]AMINO}AZEPAN-3-YL)ISONICOTINAMIDE, ... (4 entities in total)
• 機能のキーワード: pka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Cytoplasm: P00517
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43474.47

構造登録者

Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B. (登録日: 2004-09-17, 公開日: 2005-09-17, 最終更新日: 2011-07-13)

• 主引用文献: Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B.; Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants; J.Med.Chem., 48:163-170, 2005; PubMed: 15634010; DOI: 10.1021/jm049701n

実験手法

X-RAY DIFFRACTION (1.9 Å)