Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1XH4

Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

1XH4 の概要
エントリーDOI10.2210/pdb1xh4/pdb
関連するPDBエントリー1SVE 1SVG 1SVH 1VEB 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA
分子名称cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, N-[4-({4-[5-(DIMETHYLAMINO)-2-HYDROXYBENZOYL]BENZOYL}AMINO)AZEPAN-3-YL]ISONICOTINAMIDE, ... (4 entities in total)
機能のキーワードpka, kinase-inhibitor-complex, serine/threonine-protein kinase, balanol derivative, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Bos taurus (cattle)
詳細
細胞内の位置Cytoplasm: P00517
タンパク質・核酸の鎖数2
化学式量合計43514.38
構造登録者
主引用文献Breitenlechner, C.B.,Friebe, W.-G.,Brunet, E.,Werner, G.,Graul, K.,Thomas, U.,Kuenkele, K.-P.,Schaefer, W.,Gassel, M.,Bossemeyer, D.,Huber, R.,Engh, R.A.,Masjost, B.
Design and crystal structures of protein kinase B-selective inhibitors in complex with protein kinase A and mutants
J.Med.Chem., 48:163-170, 2005
Cited by
PubMed: 15634010
DOI: 10.1021/jm049701n
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.45 Å)
構造検証レポート
Validation report summary of 1xh4
検証レポート(詳細版)ダウンロードをダウンロード

217705

件を2024-03-27に公開中

PDB statisticsPDBj update infoContact PDBjnumon