1WU1

Factor Xa in complex with the inhibitor 4-[(5-chloroindol-2-yl)sulfonyl]-2-(2-methylpropyl)-1-[[5-(pyridin-4-yl) pyrimidin-2-yl]carbonyl]piperazine

1WU1 の概要

• エントリーDOI: 10.2210/pdb1wu1/pdb
• 関連するPDBエントリー: 1V3X
• 分子名称: Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00742 P00742
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 37351.74

構造登録者

Suzuki, M. (登録日: 2004-11-29, 公開日: 2005-11-29, 最終更新日: 2023-10-25)

• 主引用文献: Komoriya, S.,Haginoya, N.,Kobayashi, S.,Nagata, T.,Mochizuki, A.,Suzuki, M.,Yoshino, T.,Horino, H.,Nagahara, T.,Suzuki, M.,Isobe, Y.,Furugoori, T.; Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites; Bioorg.Med.Chem., 13:3927-3954, 2005; PubMed: 15911309; DOI: 10.1016/j.bmc.2005.04.006

実験手法

X-RAY DIFFRACTION (2.3 Å)