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1W8C

CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2

Summary for 1W8C
Entry DOI10.2210/pdb1w8c/pdb
Related4CFM 4CFN 4CFU 4CFV 4CFW 4CFX
DescriptorCELL DIVISION PROTEIN KINASE 2, 6-(CYCLOHEXYLMETHOXY)-8-ISOPROPYL-9H-PURIN-2-AMINE (3 entities in total)
Functional Keywordstransferase, cell cycle, phosphorylation, mitosis, inhibition, cell division
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains1
Total formula weight34323.90
Authors
Pratt, D.J.,Endicott, J.A.,Noble, M.E.M. (deposition date: 2004-09-20, release date: 2006-08-30, Last modification date: 2019-03-06)
Primary citationCarbain, B.,Paterson, D.J.,Anscombe, E.,Campbell-Dexter, A.,Cano, C.,Echalier, A.,Endicott, J.,Golding, B.T.,Haggerty, K.,Hardcastle, I.R.,Jewsbury, P.J.,Newell, D.R.,Noble, M.,Roche, C.,Wang, L.,Griffin, R.J.
8-Substituted O6-Cyclohexylmethylguanine Cdk2 Inhibitors; Using Structure-Based Inhibitor Design to Optimise an Alternative Binding Mode.
J.Med.Chem., 57:56-, 2014
Cited by
PubMed: 24304238
DOI: 10.1021/JM401555V
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

217705

건을2024-03-27부터공개중

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