1V1R

CROSSTALK BETWEEN COFACTOR BINDING AND THE PHOSPHORYLATION LOOP CONFORMATION IN THE BCKD MACHINE

Summary for 1V1R

Entry DOI	10.2210/pdb1v1r/pdb
Related	1DTW 1OLS 1OLU 1OLX 1V11 1V16 1V1M
Descriptor	2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	oxidoreductase, ketoacid dehydrogenase, multi-enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamin diphosphate, phosphorylation, flavoprotein
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	2
Total formula weight	83917.09
Authors	Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T. (deposition date: 2004-04-22, release date: 2004-06-03, Last modification date: 2023-12-13)
Primary citation	Li, J.,Wynn, R.M.,Machius, M.,Chuang, J.L.,Karthikeyan, S.,Tomchick, D.R.,Chuang, D.T. Cross-Talk between Thiamin Diphosphate Binding and Phosphorylation Loop Conformation in Human Branched-Chain {Alpha}-Keto Acid Decarboxylase/Dehydrogenase J.Biol.Chem., 279:32968-, 2004 Cited by PubMed: 15166214 DOI: 10.1074/JBC.M403611200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation