1UZ9

Crystallographic and solution studies of N-lithocholyl insulin: a new generation of prolonged-acting insulins.

Summary for 1UZ9

• Entry DOI: 10.2210/pdb1uz9/pdb
• Related: 1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LNP 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1SJT 1SJU 1TRZ 1TYL 1TYM 1VKT 1XDA 1XGL 1ZEG 1ZEH 1ZNJ 2AIY 2HIU 3AIY 4AIY 5AIY
• Descriptor: INSULIN, M-CRESOL, (2S)-2-AMINO-6-({(4R)-4-[(10R,13S)-10,13-DIMETHYL-3-OXOHEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHREN-17-YL]PENTANOYL}AMINO)HEXANOIC ACID, ... (7 entities in total)
• Functional Keywords: insulin, diabetes mellitus, insulin family, hormone disease mutation
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P01308 P01308
• Total number of polymer chains: 2
• Total formula weight: 6428.28

Authors

Whittingham, J.L.,Jonassen, I.,Havelund, S.,Roberts, S.M.,Dodson, E.J.,Verma, C.S.,Wilkinson, A.J.,Dodson, G.G. (deposition date: 2004-03-08, release date: 2005-03-03, Last modification date: 2023-12-13)

• Primary citation: Whittingham, J.L.,Jonassen, I.,Havelund, S.,Roberts, S.M.,Dodson, E.J.,Verma, C.S.,Wilkinson, A.J.,Dodson, G.G.; Crystallographic and Solution Studies of N-Lithocholyl Insulin: A New Generation of Prolonged-Acting Human Insulins; Biochemistry, 43:5987-, 2004; PubMed: 15147182; DOI: 10.1021/BI036163S

Experimental method

X-RAY DIFFRACTION (1.6 Å)